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Cancer Discov. 2012 Nov;2(11):976-8. doi: 10.1158/2159-8290.CD-12-0435.

Fingerprinting acute leukemia: DNA methylation profiling of B-acute lymphoblastic leukemia.

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1
Department of Pathology and Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA.

Abstract

In this issue of Cancer Discovery, Geng and colleagues report on their use of a combination of promoter cytosine methylation profiling with gene expression and ChIP sequencing to elucidate molecular signatures of adult B-acute lymphoblastic leukemia patient samples with BCR-ABL1, E2A-PBX1, and MLL rearrangements. The unique epigenetic and gene expression signatures of these clinically unfavorable B-ALL subtypes identify novel biomarkers and provide a strong rationale for repurposing existing therapies to treat these molecularly distinct diseases.

PMID:
23148371
PMCID:
PMC4307588
DOI:
10.1158/2159-8290.CD-12-0435
[Indexed for MEDLINE]
Free PMC Article
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