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J Occup Environ Med. 2013 Feb;55(2):198-208. doi: 10.1097/JOM.0b013e3182728eab.

Risk of selected cancers due to occupational exposure to chlorinated solvents in a case-control study in Montreal.

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  • 1University of Montreal Hospital Research Center, Montreal, Quebec, Canada.

Abstract

OBJECTIVE:

To evaluate the association between exposure to chlorinated solvents and cancer.

METHODS:

We conducted a case-control study of occupational exposures and cancer in Montreal, Quebec, Canada, including 3730 cancer cases and 533 population controls. Occupational exposures were derived using a combination of subject-reported job history and expert assessment. We examined the associations between two chemical families and six chlorinated solvents with 11 sites of cancer.

RESULTS:

The majority of the associations examined were null, although many were based on small numbers. We found two significantly elevated odds ratios (ORs), one between perchloroethylene and prostate cancer (OR = 4.3; 95% CI: 1.4 to 13) and another between trichloroethylene and melanoma (OR = 3.2; 95% CI: 1.0 to 9.9).

CONCLUSIONS:

There was little evidence of associations between chlorinated solvents and cancer. Limited power precludes strong inferences about absence of risk. We raise hypotheses about two possible associations: perchloroethylene with prostate cancer and trichloroethylene with melanoma.

PMID:
23147555
DOI:
10.1097/JOM.0b013e3182728eab
[PubMed - indexed for MEDLINE]
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