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J Pharm Sci. 2013 Jan;102(1):34-42. doi: 10.1002/jps.23359. Epub 2012 Nov 12.

The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development.

Author information

1
Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California 94143-0912, USA. leslie.benet@ucsf.edu

Abstract

Biopharmaceutics Classification System and Biopharmaceutics Drug Distribution Classification System are complimentary, not competing, classification systems that aim to improve, simplify, and speed drug development. Although both systems are based on classifying drugs and new molecular entities into four categories using the same solubility criteria, they differ in the criterion for permeability and have different purposes. Here, the details and applications of both systems are reviewed with particular emphasis of their role in drug development.

PMID:
23147500
PMCID:
PMC3684558
DOI:
10.1002/jps.23359
[Indexed for MEDLINE]
Free PMC Article

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