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Pharmacology. 2013;91(1-2):20-8. doi: 10.1159/000343764. Epub 2012 Nov 7.

Effect of mycophenolic acid on cyclosporin A-induced fibronectin expression in rat mesangial cells.

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1
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

Abstract

This study was undertaken to determine if mycophenolic acid (MPA) inhibits the profibrotic action of cyclosporin A (CsA) and, if so, to determine the molecular mechanisms involved. The effect of MPA treatment on CsA-induced signaling through the transforming growth factor-β (TGF-β)/Smad pathway was evaluated by immunoblot analysis in cultured primary rat mesangial cells. Treatment of cells with 1 µmol/l MPA did not significantly decrease the CsA-induced expression of TGF-β(1), but partially reversed the increases in Smad3 phosphorylation and fibronectin (FBN) production, and increased Smad7 expression. These results suggest that MPA may ameliorate CsA-induced FBN production by modulating the Smad signaling pathway. This study provides evidence that MPA can attenuate CsA-induced renal injury after kidney transplantation.

PMID:
23146841
DOI:
10.1159/000343764
[Indexed for MEDLINE]
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