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Curr Opin Cell Biol. 2012 Dec;24(6):744-56. doi: 10.1016/j.ceb.2012.10.004. Epub 2012 Nov 9.

Aging and reprogramming: a two-way street.

Author information

1
Department of Genetics, Stanford University, Stanford, CA 94305, USA.

Abstract

Aging is accompanied by the functional decline of cells, tissues, and organs, as well as a striking increase in a wide range of diseases. The reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) opens new avenues for the aging field and has important applications for therapeutic treatments of age-related diseases. Here we review emerging studies on how aging and age-related pathways influence iPSC generation and property. We discuss the exciting possibility that reverting to a pluripotent stem cell stage erases several deficits associated with aging and offers new strategies for rejuvenation. Finally, we argue that reprogramming provides a unique opportunity to model aging and perhaps exceptional longevity.

PMID:
23146768
PMCID:
PMC3540161
DOI:
10.1016/j.ceb.2012.10.004
[Indexed for MEDLINE]
Free PMC Article
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