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Biomaterials. 2013 Jan;34(4):1281-8. doi: 10.1016/j.biomaterials.2012.10.025. Epub 2012 Nov 9.

Formulations for trans-tympanic antibiotic delivery.

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Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.


We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs--bupivacaine, limonene, sodium dodecyl sulfate); this was also seen by CPEs contained within a hydrogel (poloxamer 407) to maintain the formulation at the TM. The CPE-hydrogel formulation had minimal effects on auditory thresholds and tissue response in vivo. CPE-hydrogel formulations have potential for ototopical delivery of ciprofloxacin for the treatment of acute otitis media (AOM) and other middle ear diseases.

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