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Psychiatry Res. 2013 Jan 30;211(1):85-7. doi: 10.1016/j.pscychresns.2012.06.009. Epub 2012 Nov 10.

Smoker-nonsmoker differences in neural response to smoking-related and affective cues: an fMRI investigation.

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Department of Psychology and the Integrative Neuroscience Laboratory, Southern Illinois University, Carbondale, IL, USA.


Smoking may sensitize brain systems to smoking cues while desensitizing systems to naturalistic rewards. This study examined smoker-nonsmoker differences in functional magnetic resonance imaging (fMRI) blood oxygen level dependent (BOLD) response to smoking-related and emotional images. Smokers, relative to nonsmokers, exhibited greater reactivity to smoking and decreased reactivity to emotional cues in the left middle frontal gyrus.

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