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J Small Anim Pract. 2012 Dec;53(12):673-8. doi: 10.1111/j.1748-5827.2012.01301.x. Epub 2012 Nov 12.

Circulating natriuretic peptide concentrations in hyperthyroid cats.

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1
Department of Veterinary Clinical Sciences, The Royal Veterinary College, North Mymms, Hertfordshire, UK.

Abstract

OBJECTIVES:

To assess the influence of thyroid function on natriuretic peptide concentration in hyperthyroid cats before and after treatment.

METHODS:

Serum natriuretic peptide concentration was measured in 61 hyperthyroid cats recruited from first-opinion clinics before and after treatment.

RESULTS:

Following successful treatment, total thyroxine, heart rate, systolic blood pressure and packed cell volume all decreased and bodyweight and creatinine concentrations increased. Furthermore, a significant (P < 0·001) decline in NT-proBNP concentration but not NT-proANP was identified.

CLINICAL SIGNIFICANCE:

Thyroid function has a modest but significant effect on NT-proBNP concentration. Thyroid status should be taken into account when interpreting NT-proBNP concentrations in cats.

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