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J Pharm Pharmacol. 2012 Dec;64(12):1703-8. doi: 10.1111/j.2042-7158.2012.01561.x. Epub 2012 Jul 4.

Role of fetuin-A in atherosclerosis associated with diabetic patients.

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Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut Department of Pharmaceutical Technology, Divya Jyoti College of Pharmacy, Modinagar, Uttar Pradesh, India.



Fetuin-A is a circulating glycoprotein, formed in the liver. It regulates bone remodelling and calcium metabolism. Fetuin-A has adipogenic properties, so fat accumulation in the liver may be associated with higher levels of fetuin-A. Fetuin-A is an inhibitor of the phosphorylation of the insulin receptor tyrosine kinase.


High concentrations of fetuin-A in humans causes insulin resistance. Insulin sensitivity is also found to be increased in fetuin-A knockout mice. Fetuin-A has been shown to cause insulin resistivity in type-2 diabetes mellitus and worsens the pro-atherogenic milieu.


Fetuin-A should be considered as a hepatic bio-marker. Vascular diseases like atherosclerosis are major causes of disability in patients with diabetes mellitus.

[Indexed for MEDLINE]

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