Format

Send to

Choose Destination
See comment in PubMed Commons below
PLoS One. 2012;7(11):e48107. doi: 10.1371/journal.pone.0048107. Epub 2012 Nov 7.

Distinct contributions of the dorsolateral prefrontal and orbitofrontal cortex during emotion regulation.

Author information

1
Stockholm Brain Institute, Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden. armita.golkar@ki.se

Abstract

The lateral prefrontal and orbitofrontal cortices have both been implicated in emotion regulation, but their distinct roles in regulation of negative emotion remain poorly understood. To address this issue we enrolled 58 participants in an fMRI study in which participants were instructed to reappraise both negative and neutral stimuli. This design allowed us to separately study activations reflecting cognitive processes associated with reappraisal in general and activations specifically related to reappraisal of negative emotion. Our results confirmed that both the dorsolateral prefrontal cortex (DLPFC) and the lateral orbitofrontal cortex (OFC) contribute to emotion regulation through reappraisal. However, activity in the DLPFC was related to reappraisal independently of whether negative or neutral stimuli were reappraised, whereas the lateral OFC was uniquely related to reappraisal of negative stimuli. We suggest that relative to the lateral OFC, the DLPFC serves a more general role in emotion regulation, perhaps by reflecting the cognitive demand that is inherent to the regulation task.

PMID:
23144849
PMCID:
PMC3492343
DOI:
10.1371/journal.pone.0048107
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Support Center