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Head Neck Pathol. 2013 Sep;7(3):274-9. doi: 10.1007/s12105-012-0408-x. Epub 2012 Nov 11.

Granular cell tumor of the cervical esophagus: case report and literature review of an unusual cause of Dysphagia.

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  • 1Department of Otolaryngology-Head and Neck Surgery, Virginia Commonwealth University, Box 980146, Richmond, VA 23298, USA. athuang@mdanderson.org

Abstract

Granular cell tumors (GCT) of the head and neck are not uncommon; however, involvement of the cervical esophagus is rare. Characterized by an infiltrative growth pattern, these benign tumors are historically difficult to surgically excise and are radioresistant. We present here a case of dysphagia caused by a GCT of the cervical esophagus. Work up with ultrasound-guided fine needle aspiration was suggestive of a GCT due to the presence of cohesive cells with granular cytoplasm that were S-100 and CD68 positive with immunostaining, and PAS positive with histochemistry. Resection required removal of a portion of the muscular wall of the esophagus sparing the overlying mucosa. The patient is currently asymptomatic and without recurrence after 10 month follow-up. Review of the literature revealed 19 reports of cervical esophageal GCTs. There is a female preponderance (75%), with an average age of 41 years. Dysphagia and weight loss are the most common presenting symptoms. The average tumor size on presentation was 2.7 cm, with symptomatic tumors being significantly larger than asymptomatic lesions; the latter was present in 25% of patients. Concurrent GCTs in the upper aerodigestive tract were identified in 35% of cases. Approximately 30% of tumors required segmental cervical esophageal resection. The purpose of this report is to describe the epidemiology and treatment of GCTs of the cervical esophagus. Lesions should be addressed early with complete surgical excision to prevent growth necessitating more morbid surgery. Due to the high rate of concurrent GCTs, upper endoscopy is advised in the workup of these patients.

PMID:
23143390
PMCID:
PMC3738753
DOI:
10.1007/s12105-012-0408-x
[PubMed - indexed for MEDLINE]
Free PMC Article
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