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Infect Control Hosp Epidemiol. 2012 Dec;33(12):1250-4. doi: 10.1086/668438. Epub 2012 Oct 25.

Epidemiology of vancomycin-resistant enterococci with reduced susceptibility to daptomycin.

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1
Department of Pharmacy Services, Detroit Medical Center, Detroit, Michigan, USA.

Abstract

A retrospective case-case control study was conducted, including 60 cases with daptomycin-nonsusceptible vancomycin-resistant enterococci (DNS-VRE) matched to cases with daptomycin-susceptible VRE and to uninfected controls (1∶1∶3 ratio). Immunosuppression, presence of comorbid conditions, and prior exposure to antimicrobials were independent predictors of DNS-VRE, although prior daptomycin exposure occurred rarely. In summary, a case-case control study identified independent risk factors for the isolation of DNS-VRE: immunosuppression, multiple comorbid conditions, and prior exposures to cephalosporines and metronidazole.

PMID:
23143365
DOI:
10.1086/668438
[Indexed for MEDLINE]

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