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Dalton Trans. 2013 Jan 28;42(4):1267-77. doi: 10.1039/c2dt31337e.

The influence of RAPTA moieties on the antiproliferative activity of peripheral-functionalised poly(salicylaldiminato) metallodendrimers.

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  • 1Department of Chemistry, University of Cape Town, Rondebosch, 7701 Cape Town, South Africa.

Abstract

Cationic N,O-chelating dendrimers functionalised on the periphery with RAPTA-like (ruthenium(II)-arene-1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane) moieties have been synthesised and characterised using NMR and IR spectroscopy, elemental analysis and MALDI-TOF/HR-ESI mass spectrometry. Metallodendrimers from the first to the fourth-generation containing up to 32 peripheral ruthenium-arene-PTA moieties were obtained. Model mononuclear analogues, [{Ru(η(6)-p-cymene)((C(7)H(5)NO)-κ(2)-N,O)(PTA)}((CH(2))(3))][PF(6)] and [{Ru(η(6)hexamethylbenzene)((C(7)H(5)NO)-κ(2)-N,O)(PTA)}((CH(2))(3))][PF(6)], have been prepared and their structures were determined by single crystal X-ray diffraction analysis. The cytotoxicities of the metallodendrimers and their mononuclear analogues were established on A2780 and A2780cisR human ovarian carcinoma cancer cells and model human embryonic kidney (HEK) cells.

PMID:
23143220
DOI:
10.1039/c2dt31337e
[PubMed - indexed for MEDLINE]
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