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Org Biomol Chem. 2012 Dec 28;10(48):9519-22. doi: 10.1039/c2ob26636a. Epub 2012 Nov 12.

Potassium iodide catalyzed simultaneous C3-formylation and N-aminomethylation of indoles with 4-substituted-N,N-dimethylanilines.

Author information

1
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, 94 Weijin Road, Tianjin 300071, China.

Abstract

A one-pot dual functionalization of indoles has been developed. The simultaneous C3-formylation and N-aminomethylation of indoles can be achieved using readily available potassium iodide as a catalyst and tert-butyl peroxybenzoate as a co-oxidant.

PMID:
23143045
DOI:
10.1039/c2ob26636a
[Indexed for MEDLINE]

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