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Cancer Lett. 2013 Feb 28;329(2):137-45. doi: 10.1016/j.canlet.2012.10.036. Epub 2012 Nov 8.

Cidofovir treatment improves the pathology caused by the growth of human papillomavirus-positive cervical carcinoma xenografts in athymic nude mice.

Author information

1
Rega Institute, Laboratory of Virology and Chemotherapy, K.U.L, Leuven, Belgium.

Abstract

Cidofovir has shown antiproliferative effects against human papillomavirus (HPV)-positive cells and successfully suppressed the growth of HPV-positive xenografts in athymic nude mice. The present study evaluated the effect of cidofovir on several disease parameters in this animal model. Intratumoral administration of cidofovir resulted in a beneficial effect on body weight gain, a reduction in splenomegaly, a partial restoration of tryptophan catabolism, and diminished the inflammatory state induced by the xenografts. Administration of cidofovir to tumor-free animals did not have a direct effect on these parameters. Beyond suppressing tumor growth, intratumoral treatment with cidofovir ameliorated the pathology associated with HPV-tumor growth.

PMID:
23142293
DOI:
10.1016/j.canlet.2012.10.036
[Indexed for MEDLINE]

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