Send to

Choose Destination
Psychiatry Res. 2012 Oct 30;204(1):32-9. doi: 10.1016/j.pscychresns.2012.09.009. Epub 2012 Nov 9.

Reduced insular volume in attention deficit hyperactivity disorder.

Author information

The Brain Institute, University of Utah, 383 Colorow Drive, Salt Lake City, UT 84108, United States.


The aim of this study was to evaluate whether structural differences in the insula and anterior cingulate cortex (ACC), two critical areas of the "salience network," co-exist in adolescents with attention deficit hyperactivity disorder (ADHD) compared with healthy controls (HC). In addition we aimed to determine if structural changes within these regions correlate with attention and inhibitory function. Nineteen adolescents with ADHD and 25 HC received MRI scans on a 3T magnet. Morphometric analysis was performed with FreeSurfer. Youths with ADHD were found to have a bilateral reduction in anterior insular (AIC) gray matter volumes compared to HC. Furthermore, the left AIC was found to positively correlate with oppositional symptoms, while the right AIC was found to associate with both attention problems and inhibition. To our knowledge this is the first report of a bilateral reduction in AIC volumes in ADHD. Our findings suggest a role for the insula in modulating attention and inhibitory capacity in ADHD.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center