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Structure. 2012 Nov 7;20(11):1801-4. doi: 10.1016/j.str.2012.10.008.

Polo boxes come out of the crypt: a new view of PLK function and evolution.

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1
Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal. sjana@igc.gulbenkian.pt

Erratum in

  • Structure. 2012 Dec 5;20(12):2191. Bettencourt Dias, Mónica [corrected to Bettencourt-Dias, Mónica].

Abstract

Polo-like kinases (PLKs) are marked by C-terminal polo box modules with critical protein interaction and subcellular targeting roles. Slevin et al. in this issue of Structure reveal the architecture of a hidden set of polo boxes from the divergent PLK4, a critical player in centrosome duplication, shedding new light on the evolution of PLKs and their functionally related kinase ZYG-1.

PMID:
23141691
DOI:
10.1016/j.str.2012.10.008
[Indexed for MEDLINE]
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