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Curr Opin Cell Biol. 2012 Dec;24(6):845-51. doi: 10.1016/j.ceb.2012.10.008. Epub 2012 Nov 7.

Plasma membrane growth during the cell cycle: unsolved mysteries and recent progress.

Author information

1
European Institute of Chemistry and Biology, 2 rue Robert Escarpit, 33607 Pessac, France.

Abstract

Growth of the plasma membrane is as fundamental to cell reproduction as DNA replication, chromosome segregation and ribosome biogenesis, yet little is known about the underlying mechanisms. Membrane growth during the cell cycle requires mechanisms that control the initiation, location, and extent of membrane growth, as well as mechanisms that coordinate membrane growth with cell cycle progression. Recent experiments have established links between membrane growth and core cell cycle regulators. Further analysis of these links will yield insights into conserved and fundamental mechanisms of cell growth. A better understanding of the post-Golgi pathways by which membrane growth occurs will be essential for future progress.

PMID:
23141634
PMCID:
PMC3540179
DOI:
10.1016/j.ceb.2012.10.008
[Indexed for MEDLINE]
Free PMC Article

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