Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell. 2012 Nov 9;151(4):724-37. doi: 10.1016/j.cell.2012.09.043.

Nuclear aggregation of olfactory receptor genes governs their monogenic expression.

Author information

1
Program in Biomedical Sciences, University of California, San Francisco, San Francisco, CA 94158, USA.

Abstract

Gene positioning and regulation of nuclear architecture are thought to influence gene expression. Here, we show that, in mouse olfactory neurons, silent olfactory receptor (OR) genes from different chromosomes converge in a small number of heterochromatic foci. These foci are OR exclusive and form in a cell-type-specific and differentiation-dependent manner. The aggregation of OR genes is developmentally synchronous with the downregulation of lamin b receptor (LBR) and can be reversed by ectopic expression of LBR in mature olfactory neurons. LBR-induced reorganization of nuclear architecture and disruption of OR aggregates perturbs the singularity of OR transcription and disrupts the targeting specificity of the olfactory neurons. Our observations propose spatial sequestering of heterochromatinized OR family members as a basis of monogenic and monoallelic gene expression.

PMID:
23141535
PMCID:
PMC3659163
DOI:
10.1016/j.cell.2012.09.043
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center