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Ticks Tick Borne Dis. 2013 Feb;4(1-2):160-3. doi: 10.1016/j.ttbdis.2012.08.006. Epub 2012 Oct 5.

Immunization with adenoviral-vectored tick salivary gland proteins (SALPs) in a murine model of Lyme borreliosis.

Author information

  • 1Centers for Disease Control and Prevention, Division of Vector-Borne Diseases, Bacterial Disease Branch, 3156 Rampart Road, Fort Collins, CO 80521, USA. aff1@cdc.gov

Abstract

Prior exposure of vertebrate hosts to tick salivary proteins can induce specific immunity to tick infestation, as well as affording protection against tick-transmitted Borrelia burgdorferi infection in the mammalian host. Vaccination using an adenovirus expression system to deliver 4 tick salivary proteins (Ad-Salps) derived from Ixodes scapularis, Salp15, Salp25A, Salp25D, and Isac, was explored. Results indicate that vaccination with tick salivary proteins in an adenoviral vector can be used to modulate a Th1 response in the host and partially control spirochete load in immunized mice after infected tick challenge.

PMID:
23141105
PMCID:
PMC4306421
DOI:
10.1016/j.ttbdis.2012.08.006
[PubMed - indexed for MEDLINE]
Free PMC Article
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