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Trends Microbiol. 2013 Jan;21(1):31-8. doi: 10.1016/j.tim.2012.09.006. Epub 2012 Nov 8.

Ubiquitin-like proteins and their roles in archaea.

Author information

1
Department of Microbiology and Cell Science, Genetics Institute, University of Florida, Gainesville, FL 32611-0700, USA. jmaupin@ufl.edu

Abstract

This review highlights the finding that ubiquitin-like (Ubl) proteins of archaea (termed SAMPs) function not only as sulfur carriers but also as protein modifiers. UbaA (an E1 ubiquitin-activating enzyme homolog of archaea) is required for the SAMPs to be covalently attached to proteins. The SAMPs and UbaA are also needed to form sulfur-containing biomolecules (e.g., thiolated tRNA and molybdenum cofactor). These findings provide a new perspective on how Ubl proteins can serve as both sulfur carriers and protein modifiers in the absence of canonical E2 ubiquitin conjugating or E3 ubiquitin ligase enzyme homologs.

PMID:
23140889
PMCID:
PMC3534793
DOI:
10.1016/j.tim.2012.09.006
[Indexed for MEDLINE]
Free PMC Article

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