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Cell Metab. 2012 Nov 7;16(5):555-7. doi: 10.1016/j.cmet.2012.10.012.

Mining genes in type 2 diabetic islets and finding gold.

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1
Laboratory of Experimental Medicine, Medical Faculty, Universite Libre de Bruxelles, 1000 Brussels, Belgium. deizirik@ulb.ac.be

Abstract

Pancreatic β cell failure is central in the pathogenesis of type 2 diabetes (T2D), but the mechanisms involved remain unclear. Mahdi and colleagues (2012) couple global evaluation of gene expression with coexpression network analysis of human islets from T2D patients to identify SFRP4 as an early mediator of β cell dysfunction in T2D.

PMID:
23140638
DOI:
10.1016/j.cmet.2012.10.012
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