Abstract
Chromatographic separation of the 80% MeOH extract of the leaves of Ilex rotunda (IR) led to isolation of two new hemiterpene glycosides, tentatively named as rotundarpenoside A (1) and rotundarpenoside B (2), along with five known caffeoyl derivatives (3-7). The chemical structures of these compounds were elucidated using 1D/2D NMR, HR-MS, and the absolute configuration was confirmed by Mosher's method. In order to evaluate their anti-oxidative activities, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and xanthine oxidase superoxide scavenging activities (NBT) were determined.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biphenyl Compounds / chemistry
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Free Radical Scavengers / isolation & purification*
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Free Radical Scavengers / pharmacology
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Hemiterpenes / isolation & purification*
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Hemiterpenes / pharmacology
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Ilex / chemistry*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Picrates / chemistry
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Plant Leaves / chemistry
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Superoxides / chemistry
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Xanthine Oxidase / chemistry
Substances
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Biphenyl Compounds
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Free Radical Scavengers
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Glycosides
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Hemiterpenes
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Picrates
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Superoxides
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1,1-diphenyl-2-picrylhydrazyl
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Xanthine Oxidase