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Methods Mol Biol. 2013;947:383-401. doi: 10.1007/978-1-62703-131-8_28.

Zebrafish teratogenicity testing.

Author information

1
Charles River Laboratories, Horsham, PA, USA. Kimberly.Brannen@crl.com

Abstract

As a model for teratogenicity research, zebrafish are gaining popularity and creditability. Zebrafish embryos have been proven to be a highly valuable tool in genetics and developmental biology research and have advanced our understanding of a number of known developmental toxicants. It has yet to be determined conclusively how reliably a zebrafish embryo screening assay predicts what will happen in mammalian models, but results from initial assessments have been encouraging. Here we have presented procedures for the basic care of a zebrafish colony to support embryo production, embryo collection and culturing, and teratogenicity experiments.

PMID:
23138918
DOI:
10.1007/978-1-62703-131-8_28
[Indexed for MEDLINE]

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