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Inflammopharmacology. 2013 Apr;21(2):125-7. doi: 10.1007/s10787-012-0158-0. Epub 2012 Nov 9.

Do anti-TNF-α drugs increase cancer risk in rheumatoid arthritis patients?

Author information

1
Department of Medicine, Health Sciences Center Rm. 3H1E, McMaster University, 1280 Main St. West, Hamilton, ON L8S 4K1, Canada. clarkd@mcmcaster.ca

Abstract

Concern has been raised about an increased risk of lymphoma and skin cancers in patients with rheumatoid arthritis due to administration of anti-TNF-α drugs. Meta-analysis of observational data from registries as well as from randomized controlled trials has failed to show a significant increase in the risk of lymphoma when the sample size has been sufficiently large; skin cancer risk may represent a valid concern. Issues relating to interpretation of these data are discussed.

PMID:
23138614
DOI:
10.1007/s10787-012-0158-0
[Indexed for MEDLINE]

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