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J Crit Care. 2013 Oct;28(5):792-7. doi: 10.1016/j.jcrc.2012.10.003. Epub 2012 Nov 6.

Relationship between plasma high-mobility group box-1 levels and clinical outcomes of ischemic stroke.

Author information

1
Department of Neurology, The First Hospital of Jia Xing, Jiaxing, 314001, PR China. Electronic address: jiaxingjuminghuang@163.com.

Abstract

PURPOSE:

High-mobility group box-1 (HMGB1) is regarded as a central mediator of inflammation and involved in many inflammatory diseases. This study aimed to investigate impact of plasma HMGB1 level on 1-year clinical outcomes of ischemic stroke.

METHODS:

Plasma HMGB1 levels of 338 patients were quantified by enzyme-linked immunosorbent assay. The end points were mortality and unfavorable outcome (modified Rankin Scale score>2) after 1 year.

RESULTS:

Plasma HMGB1 level emerged as an independent predictor of 1-year clinical outcomes. Its prognostic value was similar to National Institutes of Health Stroke Scale score's. It improved prognostic value of National Institutes of Health Stroke Scale score.

CONCLUSION:

Plasma HMGB1 level represents a novel biomarker for predicting 1-year clinical outcomes of ischemic stroke.

KEYWORDS:

High mobility group box-1; Ischemic stroke; Outcome

PMID:
23137435
DOI:
10.1016/j.jcrc.2012.10.003
[Indexed for MEDLINE]
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