Format

Send to

Choose Destination
Tissue Antigens. 2012 Dec;80(6):477-87. doi: 10.1111/tan.12014.

Controversies in granzyme biology.

Author information

1
Cancer Cell Death Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Australia.

Abstract

Granzymes (Grz) are a family of serine proteases found in the granules of cytotoxic lymphocytes and are emerging as an important group of proteins involved in immune function and surveillance. Grz have both cytotoxic and more recently reported non-cytotoxic roles, however these functions are still subject to thorough investigation. The significance of the cytotoxic and importantly the non-cytotoxic roles of Grz will be discussed in this review, detailing accepted and controversial functions.

PMID:
23137319
DOI:
10.1111/tan.12014
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center