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Korean J Pathol. 2012 Oct;46(5):478-82. doi: 10.4132/KoreanJPathol.2012.46.5.478. Epub 2012 Oct 25.

Ghost cell odontogenic carcinoma arising from calcifying cystic odontogenic tumor: a case report.

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Department of Pathology, West China Hospital of Stomatology, Sichuan University, Sichuan, China.


Ghost cell odontogenic carcinoma (GCOC) is an exceptionally rare and malignant odontogenic tumor with aggressive growth characteristics. We describe a case of GCOC which was considerably derived from a previously resected calcifying cystic odontogenic tumor (CCOT). Cellular atypia, mitotic activity, Ki-67 labeling index and matrix metalloprotease-9 positive expression rate were all increased in the currently resected specimen compared to the initial one. This is a rare case of malignant transformation of CCOT to GCOC with respect to its histopathological and immunohistochemical findings.


Calcifying cystic odontogenic tumor; Ghost cell odontogenic carcinoma

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