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J Drugs Dermatol. 2012 Sep;11(9):1059-68.

The basic science of dermal fillers: past and present Part I: background and mechanisms of action.

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Department of Dermatology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA.


Dermal fillers have provided a safe and effective means for aesthetic soft tissue augmentation, and have experienced a dramatic increase in popularity during the past 10 years. Much focus has been placed upon filler technique and patient outcomes. However, there is a relative lack of literature reviewing the basic science of dermal fillers, which is vital to a physician's understanding of how each product behaves in vivo. Part I of this article reviews the basic science and evolution of both historical and contemporary dermal fillers; Part II examines their adverse effects. We endeavor to provide the physician with a practical approach to choosing products that maximize both aesthetic outcome and safety.

[Indexed for MEDLINE]

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