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Nat Med. 2012 Nov;18(11):1611-2. doi: 10.1038/nm.2980.

SAMHD1 does it again, now in resting T cells.

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1
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. nan.yan@utsouthwestern.edu

Abstract

A long-standing question in the HIV field is why HIV-1 fails to replicate in resting CD4(+) T cells. A new study shows that host deoxynucleoside triphosphate triphosphohydrolase (dNTPase) sterile α motif and histidine/aspartic domain-containing protein 1 (SAMHD1), previously shown to block HIV infection in myeloid cells, also restricts HIV replication in resting CD4(+) T cells by hydrolyzing dNTPs, which are needed for reverse transcription of the virus (pages 1682-1687).

PMID:
23135508
PMCID:
PMC4036678
DOI:
10.1038/nm.2980
[Indexed for MEDLINE]
Free PMC Article
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