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Biosci Rep. 2013 Feb 1;33(2):e00018. doi: 10.1042/BSR20120059.

Integration of the metabolic/redox state, histone gene switching, DNA replication and S-phase progression by moonlighting metabolic enzymes.

Author information

1
*College of Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, TEDA, Tianjin 300457, People's Republic of China.
2
†Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.
3
‡School of Basic Medical Sciences, Zhejiang University College of Medicine, No. 388, YuHangTang Road, Hangzhou, Zhejiang 310058, People's Republic of China.
4
§Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21230, U.S.A.

Abstract

The concept of one-protein-multiple-function, i.e. moonlighting proteins, is an ever-expanding paradigm. We obtained compelling evidence that an array of 'cytoplasmic' metabolic enzymes can enter the nuclei to carry out moonlighting transcription functions; this phenomenon is conserved from Drosophila to humans. Of particular interest are the classical glycolytic enzymes GAPDH (glyceraldehyde-3-phosphate dehydrogenase) and LDH (lactate dehydrogenase), which utilize NAD(H) as coenzymes and not only moonlight (in their nuclear forms) to regulate the transcription of S-phase-specific histone genes, but also act as metabolic/redox sensors that link histone gene switching to DNA replication and S-phase progression.

PMID:
23134369
PMCID:
PMC3561917
DOI:
10.1042/BSR20120059
[Indexed for MEDLINE]
Free PMC Article
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