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Biosci Biotechnol Biochem. 2012;76(11):2165-7. Epub 2012 Nov 7.

The role of acetylation in the subcellular localization of an oncogenic isoform of translation factor eIF5A.

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1
Chemical Genetics Laboratory, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

Abstract

Mammalian cells express two isoforms of eIF5A, eIF5A1 and eIF5A2, but little is known about the function of eIF5A2. Here we report that eIF5A2 is reversibly acetylated at lysine-47. HDAC6 and SIRT2 were identified as the enzymes responsible for deacetylating eIF5A2. Analysis using acetylation-deficient mutants indicated that acetylation regulates the subcellular localization of eIF5A2.

PMID:
23132580
[Indexed for MEDLINE]
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