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Stat Med. 2013 May 30;32(12):1995-2000. doi: 10.1002/sim.5672. Epub 2012 Nov 7.

Evaluation of a surrogate marker: validity and efficiency.

Author information

1
Department of Global Statistical Science, Eli Lilly and Company, Indianapolis, IN 46285, USA. quyo@lilly.com

Abstract

Statistical validation of a surrogate endpoint or surrogate marker has been studied for three decades. However, there is still no consensus on how to evaluate surrogate endpoints or surrogate markers. There is much confusion on which method should be used for the evaluation of a surrogate endpoint or surrogate marker. In this article, we clarify the statistical definitions of the surrogate endpoint and surrogate marker and introduce the concept of the validity and efficiency of a surrogate marker. We suggest the proportion of information gain can be used to evaluate the validity of a surrogate marker.

PMID:
23132288
DOI:
10.1002/sim.5672
[Indexed for MEDLINE]
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