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Org Biomol Chem. 2012 Dec 28;10(48):9601-19. doi: 10.1039/c2ob26577j. Epub 2012 Nov 7.

Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.

Author information

1
College of Liberal Arts and Sciences, Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, MI 48202, USA.

Abstract

The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.

PMID:
23132282
PMCID:
PMC4346228
DOI:
10.1039/c2ob26577j
[Indexed for MEDLINE]
Free PMC Article

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