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Nat Cell Biol. 2012 Nov;14(11):1122-3. doi: 10.1038/ncb2616.

Setting Snail2's pace during EMT.

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1
Molecular, Cellular and Developmental Biology Program, Ohio State University, and the OSU Comprehensive Cancer Center, Columbus, Ohio, USA.

Abstract

Epithelial to mesenchymal transition (EMT) is a fundamental process in both development and cancer progression. The transcription factor Elf5 is now reported as an upstream regulator of the key EMT inducer Snail2, and is shown to regulate the earliest known rewiring events required for tumour cell invasiveness and metastasis.

PMID:
23131919
DOI:
10.1038/ncb2616
[Indexed for MEDLINE]
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