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Pediatr Nephrol. 2013 Mar;28(3):499-505. doi: 10.1007/s00467-012-2346-y. Epub 2012 Nov 7.

Development and validation of a new statistical model for prognosis of long-term graft function after pediatric kidney transplantation.

Author information

1
Department of Pediatric Nephrology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany. larspape@t-online.de

Abstract

BACKGROUND:

No adequate statistical model has been established to estimate future glomerular filtration rate (GFR) in children after kidney transplantation (KTX). Equations based on simple linear regression analysis as used in adults are not established in children.

METHODS:

An optimal prognostic model of GFR was generated for 63 children at 3-7 years after KTX. The main regression model for prediction of the log-transformed GFR (logGFR) included the mean monthly change of GFR in the period 3-24 months after KTX (∆GFR), the baseline GFR at 3 months (bGFR), and an intercept. Additionally, we investigated if the inclusion of cofactors leads to more precise predictions. The model was validated by leave-one-out cross-validation for years 3-7 after KTX. Prognostic quality was determined with the mean squared error (MSE) and mean absolute error (MAE). Results were compared with the simple linear regression model used in adults.

RESULTS:

The following statistical model was calculated for every prognosis year (i = 3, …, 7):[Formula: see text] [Formula: see text] Comparison of the new statistical model and the simple linear model for adults led to relevantly lower MSEs and MAEs for the new model (year 7: New model: MSE 0.1, MAE 0.3/adult model: MSE 1069, MAE 18). The benefit of inclusion of cofactors was not relevant.

CONCLUSIONS:

This statistical model is able to predict long-term graft function in children with very high precision.

PMID:
23131863
DOI:
10.1007/s00467-012-2346-y
[Indexed for MEDLINE]
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