Format

Send to

Choose Destination
See comment in PubMed Commons below
Transcription. 2013 Jan-Feb;4(1):7-12. doi: 10.4161/trns.22300. Epub 2012 Nov 6.

How to stop: the mysterious links among RNA polymerase II occupancy 3' of genes, mRNA 3' processing and termination.

Author information

1
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR 7104, INSERM U 964, Université de Strasbourg, Illkirch Cedex, France.

Abstract

Eukaryotic genes are transcribed by RNA polymerase II (RNAP II) through cycles of initiation, elongation and termination. Termination remains the least understood stage of transcription. Here we discuss the role of RNAP II occupancy downstream of the 3'ends of genes and its links with termination and mRNA 3' processing.

KEYWORDS:

End of Annotated Gene; RNA Polymerase II pause; core histone genes; genome-wide mapping; polyadenylation; transcription termination

PMID:
23131668
PMCID:
PMC3644043
DOI:
10.4161/trns.22300
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis Icon for PubMed Central
    Loading ...
    Support Center