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Transcription. 2013 Jan-Feb;4(1):13-7. doi: 10.4161/trns.22542. Epub 2012 Nov 6.

Two faces of brd4: mitotic bookmark and transcriptional lynchpin.

Author information

1
Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD, USA.

Abstract

The bromodomain protein BRD4 links cell cycle and transcription, bookmarking active genes during mitosis and serving as a scaffold for transcription factors. Our recent discovery that BRD4 is a RNA Polymerase II CTD kinase identifies a novel transcriptional function. Here we discuss our model in the context of current knowledge.

KEYWORDS:

Atypical kinase; BET protein; BRD4; CTD kinase; P-TEFb; RNA Polymerase II

PMID:
23131666
PMCID:
PMC3644036
DOI:
10.4161/trns.22542
[Indexed for MEDLINE]
Free PMC Article

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