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Transcription. 2013 Jan-Feb;4(1):18-23. doi: 10.4161/trns.22601. Epub 2012 Nov 6.

Genomic occupancy of the transcriptional co-activators p300 and CBP.

Author information

1
The Wenner-Gren Institute, Developmental Biology, Stockholm University, Arrheniuslaboratories E3, SE-106 91 Stockholm, Sweden.

Abstract

The p300 and CBP co-activators are histone acetylases and central regulators of transcription in metazoans. The genomic occupancy of p300/CBP detected by ChIP-seq experiments can be used to identify transcriptional enhancers. However, studies in Drosophila embryos suggest that there is a preference for some transcription factors in directing p300/CBP to the genome. Although p300/CBP occupancy in general correlates with gene activation, they can also be found at silent genomic regions, which does not result in histone acetylation. Polycomb-mediated H3K27me3 is associated with repression, but does not preclude p300/CBP binding. An antagonism between H3K27ac and H3K27me3 indicates that p300/CBP may be involved in switching between repressed and active chromatin states.

KEYWORDS:

CBP; ChIP-seq; Polycomb; enhancer; p300; transcription

PMID:
23131664
PMCID:
PMC3644037
DOI:
10.4161/trns.22601
[Indexed for MEDLINE]
Free PMC Article
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