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Complement Ther Med. 2012 Dec;20(6):434-6. doi: 10.1016/j.ctim.2012.07.010. Epub 2012 Aug 29.

Anti-tuberculosis activity of Indian grass KHUS (Vetiveria zizanioides L. Nash).

Author information

1
Molecular Bioprospection Department of Biotechnology Division, CSIR - Central Institute of Medicinal and Aromatic Plants, Lucknow, India.

Abstract

AIMS & OBJECTIVES:

Vetiveria zizanioides L. Nash (Family: Poaceae) root (intact and spent) extracts and fractions were evaluated for antimycobacterial activity against Mycobacterium tuberculosis H(37)Rv and H(37)Ra strains using radiometric BACTEC 460 TB system.

METHODS & RESULTS:

The ethanolic extract of intact as well as spent root were showed potent antituberculosis activity at a minimum concentration of 500μg/mL. The hexane fraction also showed antibacterial action by recording continuous decline in growth index (GI) of M. tuberculosis at 50μg/mL. It was furthermore observed that root extract and hexane fraction showed activity even after the extraction of essential oil by hydro-distillation.

CONCLUSION:

Our results suggest that ethanolic extract and hexane fraction exhibited potent antimycobacterial activity.

SIGNIFICANCE AND IMPACT OF THE STUDY:

The observed potential inhibitory characteristic not only supports the traditional medicinal uses of vetiver but also signify a promising candidature of root extract and hexane fraction of V. zizanioides as an antituberculosis agent.

PMID:
23131375
DOI:
10.1016/j.ctim.2012.07.010
[Indexed for MEDLINE]

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