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Bioorg Med Chem Lett. 2012 Dec 15;22(24):7376-80. doi: 10.1016/j.bmcl.2012.10.074. Epub 2012 Oct 23.

Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat.

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1
Corcept Therapeutics, 149 Commonwealth Drive, Menlo Park, CA 94025, USA. hhunt@corcept.com

Abstract

We report the optimization of a series of non-steroidal GR antagonists that led to the identification of compound 7. This compound is efficacious when dosed orally in an olanzapine-induced weight gain model in rats.

PMID:
23131342
DOI:
10.1016/j.bmcl.2012.10.074
[Indexed for MEDLINE]
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