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Ann Lab Med. 2012 Nov;32(6):429-32. doi: 10.3343/alm.2012.32.6.429. Epub 2012 Oct 17.

Sensitization to multiple rh antigens by transfusion of random donor platelet concentrates in a -D- phenotype patient.

Author information

1
Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

The -D- phenotype is a rare Rh phenotype that strongly expresses D antigen without C, c, E, or e antigens. In -D- phenotype individuals, anti-Rh17 (Hr(o)) is commonly found if there is a history of pregnancy or transfusion with red blood cells (RBCs) that express C, c, E, or e antigens. We report the first case of a -D- phenotype patient with multiple Rh antibodies including anti-Rh17 who had a history of two occasions of transfusion with eight random donor platelet concentrates two and six years ago. We found that a trivial amount of RBCs in the platelet components was able to trigger sensitization to RBC antigens, especially the highly immunogenic and clinically significant Rh antigens, including C, c, E, e or CcEe polypeptides. To avoid unnecessary sensitization and to minimize the risk of hemolytic transfusion reactions in patients with this rare Rh phenotype, a modified strategy for pretransfusion screenings needs to be discussed in the field of transfusion medicine.

KEYWORDS:

Platelet transfusion; Rh isoimmunization; Rh-Hr blood group system

PMID:
23130343
PMCID:
PMC3486938
DOI:
10.3343/alm.2012.32.6.429
[Indexed for MEDLINE]
Free PMC Article

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