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Asia Pac Allergy. 2012 Oct;2(4):280-2. doi: 10.5415/apallergy.2012.2.4.280. Epub 2012 Oct 31.

Biphasic anaphylaxis to gemifloxacin.

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Department of Chest Diseases, Faculty of Medicine, Erciyes University, Kayseri 38030, Turkey.


Anaphylaxis have been documented as adverse effects of ciprofloxacin, ofloxacin, norfloxacin, levofloxacin, and moxifloxacin. However resistant and biphasic anaphlylactic reactions to gemifloxacin have not been reported to date. Management of severe anaphylaxis in the elderly can be complicated by concurrent medications such as beta (β) adrenergic, alpha (α) adrenergic blockers and angiotensin-converting enzyme (ACE) inhibitors. We report here in the case of a 60-year-old male who was taking on ACE inhibitor, α and β blockers and experienced a severe, resistant and biphasic anaphlylactic reaction to gemifloxacin mesylate.


ACE inhibitor; Alpha blocker; Beta blocker; Biphasic anaphylaxis; Gemifloxacin

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