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Acta Biomater. 2013 Nov;9(10):8730-9. doi: 10.1016/j.actbio.2012.10.035. Epub 2012 Nov 2.

Experimental data confirm numerical modeling of the degradation process of magnesium alloys stents.

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Laboratory of Biological Structure Mechanics, Structural Engineering Department, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133 Milan, Italy. Electronic address:


Biodegradable magnesium alloy stents (MAS) could present improved long-term clinical performances over commercial bare metal or drug-eluting stents. However, MAS were found to show limited mechanical support for diseased vessels due to fast degradation. Optimizing stent design through finite element analysis (FEA) is an efficient way to improve such properties. Following previous FEA works on design optimization and degradation modeling of MAS, this work carried out an experimental validation for the developed FEA model, thus proving its practical applicability of simulating MAS degradation. Twelve stent samples of AZ31B were manufactured according to two MAS designs (an optimized one and a conventional one), with six samples of each design. All the samples were balloon expanded and subsequently immersed in D-Hanks' solution for a degradation test lasting 14 days. The experimental results showed that the samples of the optimized design had better corrosion resistance than those of the conventional design. Furthermore, the degradation process of the samples was dominated by uniform and stress corrosion. With the good match between the simulation and the experimental results, the work shows that the FEA numerical modeling constitutes an effective tool for design and thus the improvement of novel biodegradable MAS.


Corrosion; Design optimization; Finite element analysis; Magnesium alloy stents; Model validation

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