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Br J Clin Pharmacol. 2013 Jun;75(6):1381-95. doi: 10.1111/bcp.12025.

Antifungal agents and therapy for infants and children with invasive fungal infections: a pharmacological perspective.

Author information

1
Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.

Abstract

Invasive fungal infections, although relatively rare, are life-threatening diseases in premature infants and immunocompromised children. While many advances have been made in antifungal therapeutics in the last two decades, knowledge of the pharmacokinetics and pharmacodynamics of antifungal agents for infants and children remains incomplete. This review summarizes the pharmacology and clinical utility of currently available antifungal agents and discusses the opportunities and challenges for future research.

PMID:
23126319
PMCID:
PMC3690098
DOI:
10.1111/bcp.12025
[Indexed for MEDLINE]
Free PMC Article

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