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Evid Based Complement Alternat Med. 2012;2012:452313. doi: 10.1155/2012/452313. Epub 2012 Oct 17.

Antidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic Patients.

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Endocrine and Diabetes Unit, Department of Molecular Medicine and Surgery, Karolinska Institute,17176 Stockholm, Sweden ; Hanoi Medical University, 1000 Hanoi, Vietnam ; National Institute of Gerontology, 1000 Hanoi, Vietnam.



To investigate the antidiabetic effect of the traditional Vietnamese herb Gynostemma pentaphyllum (GP) together with sulfonylurea (SU) in 25 drug-naïve type 2 diabetic patients.


After 4-week treatment with gliclazide (SU), 30 mg daily, all patients were randomly assigned into 2 groups to add on GP extract or placebo extract, 6 g daily, during eight weeks.


After 4-week SU treatment, fasting plasma glucose (FPG) and HbA(1C) decreased significantly (P < 0.001). FPG was further reduced after add-on therapy with 2.9 ± 1.7 and 0.9 ± 0.6 mmol/L in the GP and placebo groups, respectively (P < 0.001). Therapy with GP extract also reduced 30- and 120-minute oral glucose tolerance test postload values. HbA(1C) levels decreased approximately 2% units in the GP group compared to 0.7% unit in the placebo group (P < 0.001).


GP extract in addition to SU offers an alternative to addition of other oral medication to treat type 2 diabetic patients.

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