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Cold Spring Harb Perspect Med. 2012 Nov 1;2(11). pii: a012427. doi: 10.1101/cshperspect.a012427.

Bacterial quorum sensing: its role in virulence and possibilities for its control.

Author information

1
Department of Molecular Biology, Princeton University, New Jersey 08544, USA.

Abstract

Quorum sensing is a process of cell-cell communication that allows bacteria to share information about cell density and adjust gene expression accordingly. This process enables bacteria to express energetically expensive processes as a collective only when the impact of those processes on the environment or on a host will be maximized. Among the many traits controlled by quorum sensing is the expression of virulence factors by pathogenic bacteria. Here we review the quorum-sensing circuits of Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa, and Vibrio cholerae. We outline these canonical quorum-sensing mechanisms and how each uniquely controls virulence factor production. Additionally, we examine recent efforts to inhibit quorum sensing in these pathogens with the goal of designing novel antimicrobial therapeutics.

PMID:
23125205
PMCID:
PMC3543102
DOI:
10.1101/cshperspect.a012427
[Indexed for MEDLINE]
Free PMC Article

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