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Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12449-53. doi: 10.1002/anie.201207005. Epub 2012 Nov 4.

Single-round, multiplexed antibody mimetic design through mRNA display.

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1
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA.

Abstract

In a single round: By combining the high-efficiency enrichment through the continuous-flow magnetic separation (CFMS) technique with the analytical power of next-generation sequencing, the generation of antibody mimetics with a single round of mRNA display is made possible. This approach eliminates iterative selection cycles and provides a path to fully automated ligand generation (see picture).

PMID:
23125174
PMCID:
PMC3832244
DOI:
10.1002/anie.201207005
[Indexed for MEDLINE]
Free PMC Article
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