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Chem Commun (Camb). 2012 Dec 18;48(97):11886-8. doi: 10.1039/c2cc36982f.

Clicked europium dipicolinate complexes for protein X-ray structure determination.

Author information

1
CEA, DSV, Institut de Biologie Structurale (IBS), 41 rue Jules Horowitz, Grenoble F-38027, France.

Abstract

New trisdipicolinic acid-lanthanide complexes are reported as phasing agents for X-ray crystallography of proteins. It is demonstrated that CuAAC modifications allow protein co-crystallization with low concentration of lanthanide complexes leading to an accurate structure determination.

PMID:
23123834
DOI:
10.1039/c2cc36982f
[Indexed for MEDLINE]

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