Format

Send to

Choose Destination
Mol Immunol. 2013 Apr;53(4):421-30. doi: 10.1016/j.molimm.2012.09.013. Epub 2012 Oct 31.

Review: Endocrine disrupting chemicals and immune responses: a focus on bisphenol-A and its potential mechanisms.

Author information

1
Hotchkiss Brain Institute and the Department of Clinical Neurosciences, University of Calgary, Canada.

Abstract

Endocrine disrupting chemicals (EDCs) have become of concern for a variety f health issues. Due to their effects on the endocrine system they have been thoroughly examined with regards to sexual dysfunction, malformation, and cancers of reproductive origin. Bisphenol-A (BPA) is a widely studied EDC and has been characterized regarding its estrogenic effects on a variety of cell types. BPA also alters immune responses. In this review, we examine some of the documented effects of EDCs, with a focus on BPA that pertain to modulation of the immune system and various immune cell populations. We highlight the multiple actions of BPA on altering T cell subsets, B cell functions, and dendritic cell and macrophage biology. Finally, we consider that these immunological activities of BPA may be mediated through estrogen receptor signaling, arylhydrocarbon receptor, and the peroxisome proliferator-activated receptor family of nuclear receptors.

PMID:
23123408
DOI:
10.1016/j.molimm.2012.09.013
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center